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KH and KN contributed equally.
Contributors NT and SY developed the concept and design of the article. KH, KN, YM, NT and SY compiled and analysed the pathological data. KH and SY wrote the first draft, and all of the authors critically evaluated the manuscript.
Funding This work was supported by a research grant (20FC1006) from Grant-in-Aid for Research on rare and intractable diseases from the Ministry of Health, Labour, and Welfare of Japan.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval All experiments were approved by the ethical committee of the Kumamoto University (Senshin no. 2358), and were performed in accordance with the relevant guidelines and regulations required by the Kumamoto University.
Provenance and peer review Not commissioned; externally peer reviewed.
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