Article Text

Download PDFPDF
IgM-gammopathy strongly favours immune treatable MMN and MADSAM over ALS
  1. Shahar Shelly1,2,
  2. John R Mills1,
  3. Jennifer M Martinez-Thompson2,
  4. Matt M Rofforth1,
  5. Sean J Pittock1,2,
  6. Jay Mandrekar3,
  7. James Douglas Triplett2,
  8. Michelle Mauermann2,
  9. Divyanshu Dubey1,2,
  10. C J Klein1,2
  1. 1 Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
  2. 2 Neurology, Mayo Clinic, Rochester, Minnesota, USA
  3. 3 Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr C J Klein, Mayo Clinic, Rochester, MN 55905, USA; klein.christopher{at}

Statistics from


The early diagnosis of amyotrophic lateral sclerosis (ALS) is often difficult as not all patients meet clinical and electrophysiological criteria.1 Additionally a small per cent of patients have a divergent diagnosis, most commonly multifocal motor neuropathy (MMN) or motor-predominant multifocal acquired demyelinating sensory and motor neuropathy (MADSAM).2 Although motor conduction blocks distinguish MMN and MADSAM from ALS, it is often difficult to find these conduction abnormalities when present at the roots or plexus. Currently biomarkers to assist in the diagnosis of ALS versus MMN and MADSAM are inadequate. Specifically, GM1 (ganglioside monosialo-asialo) autoantibodies can be present in all these disorders, although typically of lower values in ALS. Recently, IgM-gammopathy was suggested to be more common in MMN (7%) compared with healthy (2%) and ALS (1%) controls.3 If true, IgM-gammopathy may forebode for an immune treatment refractory disorder as described in other IgM-gammopathy neuropathies.4

Herein, we address: (1) the occurrence of an IgM-gammopathy in MMN and MADSAM compared with ALS and (2) evaluate the immune treatment response of MMN and MADSAM IgM-monoclonal-gammopathy.


Clinical characteristics

We identified 78 MADSAM, 65 MMN cases and 412 ALS patients matched in gender and age. ALS was considered in the differential diagnosis of 51% (40/78) of MADSAM and 64% (42/65) of MMN patients due to motor predominant progressive symptoms. IgM-gammopathy was significantly (p<0.001; OR estimate of 33, 95% CI) more common in MADSAM 23% (18/78) and MMN 17% (11/65) compared with ALS<1% (2/412) (figure 1). IgM-Kappa was the most …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.