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Contributors BP and ZQ initiated the study. YH drafted the manuscript. YH and YY collected the data. SS and YD interpreted the genetic data. BH, JN and FF interpreted the imaging data. All authors revised the manuscript substantially and approved its final version.
Funding The study is supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CIFMS, 2016-12M-1-002), the National Key Research and Development Program of China (2016YFC0901004) and the Peking Union Medical College Graduate Student Innovation Fund (2016-1002-01-15).
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval Local ethics committee of Peking Union Medical College Hospital (JS-1282).
Provenance and peer review Not commissioned; externally peer reviewed.