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Distinct dopaminergic abnormalities in traumatic brain injury and Parkinson’s disease
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  • Published on:
    Dopaminergic abnormalities after subarachnoid haemorrhage
    • Matthieu Faillot, Neurosurgeon Department of Neurosurgery, Beaujon University Hospital,Greater Paris University Hospital (APHP), INSERM U955 IMRB
    • Other Contributors:
      • Jean-Marc Gurruchaga, Neurologist
      • Schahrazed Bouazza, Neurosurgeon
      • Titien Tuilier, Interventional Neuroradiologist
      • Celine Botella, Neurosurgeon
      • Imen Megdiche, Neuroradiologist
      • Emmanuel Itti, Nuclear Medicine Physician
      • Stephane Palfi, Neurosurgeon

    We read with great interest the study by Jenkins et al 1. Using dopamine transporter (DAT) 123I- Ioflupane SPECT imaging, the authors provide evidence for different patterns of dopaminergic abnormalities in patients with traumatic brain injury (TBI) and patients with Parkinson’s disease.
    We would like to report on the clinical observation of a 35-year-old patient who was admitted at our institution after an aneurysmal subarachnoid haemorrhage (SAH). The patient was initially comatose, and the CT-scan revealed an intraparenchymal haemorrhage associated with an intraventricular haemorrhage. The patient was treated with endovascular treatment and a ventricular catheter was inserted to treat SAH-associated hydrocephalus. There were no ischemic complications. Upon awakening, we observed a bilateral postural tremor affecting the upper limbs, which had already been noticed by the relatives before SAH. The patient’s father is deceased but also had a history of tremor. Our initial conclusion was that this tremor was compatible with essential tremor and required no further investigation.
    After ventriculoperitoneal shunting for hydrocephalus (complicated by overdrainage) the patient made a progressive recovery and returned to part-time work as a gardener despite the persistence of cognitive symptoms.
    One year after haemorrhage, the amplitude of the postural tremor decreased, and a dystonia affecting the right hand appeared. Upon examination 21 months after haemorr...

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    Conflict of Interest:
    None declared.