Article Text

Download PDFPDF
Encephalitis as an immune-related adverse event
  1. Shigeaki Suzuki
  1. Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan
  1. Correspondence to Dr Shigeaki Suzuki, Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan; sgsuzuki{at}z3.keio.jp

Statistics from Altmetric.com

Encephalitis as an immune-related adverse event has different features than encephalitis in regular clinical practice

With the increasing use of immune checkpoint inhibitors (ICIs), neurologists encounter more immune-related adverse events (irAEs). Since the mortality rate of encephalitis occurring as an irAE (irEncephalitis) is as high as 19%,1 it is as lethal a condition as myocarditis. Vogrig et al 2 proposed the classification of central nervous system complications associated with autoantibodies. This report is valuable for managing irEncephalitis, which shows different features than encephalitis in the usual clinical setting.

Making a diagnosis of irEncephalitis is difficult, as patients present with a broad range of clinical features. Limbic encephalitis is the most common phenotype of irEncephalitis; however, unexpected clinical features can be observed, such as those referred to as atypical …

View Full Text

Footnotes

  • Collaborators None.

  • Contributors SS was involved in all aspects of the commentary.

  • Funding This work was supported by JSPC KAKENHI Grant Number JP17K09784 and Intramural Research Grant (29-4) for Neurological and Psychiatric Disorders of NCNP.

  • Competing interests SS is a consultant/advisory board member on neurologic side effects for Ono Pharmaceutical, Bristol-Myers Squibb, MSD, Chugai and AstraZeneca.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Neuro-inflammation
    Alberto Vogrig Sergio Muñiz-Castrillo Bastien Joubert Geraldine Picard Veronique Rogemond Cécile Marchal Anne Marie Chiappa Eve Chanson François Skowron Amelie Leblanc François Ducray Jerome Honnorat