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Encephalitis as an immune-related adverse event
  1. Shigeaki Suzuki
  1. Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan
  1. Correspondence to Dr Shigeaki Suzuki, Department of Neurology, Keio University School of Medicine, Tokyo 160-8582, Japan; sgsuzuki{at}

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Encephalitis as an immune-related adverse event has different features than encephalitis in regular clinical practice

With the increasing use of immune checkpoint inhibitors (ICIs), neurologists encounter more immune-related adverse events (irAEs). Since the mortality rate of encephalitis occurring as an irAE (irEncephalitis) is as high as 19%,1 it is as lethal a condition as myocarditis. Vogrig et al 2 proposed the classification of central nervous system complications associated with autoantibodies. This report is valuable for managing irEncephalitis, which shows different features than encephalitis in the usual clinical setting.

Making a diagnosis of irEncephalitis is difficult, as patients present with a broad range of clinical features. Limbic encephalitis is the most common phenotype of irEncephalitis; however, unexpected clinical features can be observed, such as those referred to as atypical …

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  • Collaborators None.

  • Contributors SS was involved in all aspects of the commentary.

  • Funding This work was supported by JSPC KAKENHI Grant Number JP17K09784 and Intramural Research Grant (29-4) for Neurological and Psychiatric Disorders of NCNP.

  • Competing interests SS is a consultant/advisory board member on neurologic side effects for Ono Pharmaceutical, Bristol-Myers Squibb, MSD, Chugai and AstraZeneca.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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