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Effect of high-caloric nutrition on serum neurofilament light chain levels in amyotrophic lateral sclerosis

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  • JD and JS contributed equally.

  • Collaborators LIPCAL-ALS Study Group.

  • Contributors JoD, ACL, JS, MO and JeD contributed to the conception and design of the study. ACL, JoD, JS, LD, JeD, JW, JK, UW, TM, SP, AH, BJ, JG, TG, DZ, MB, BS, JP, AW, SG and and FR contributed to the acquisition and analysis of data. JoD, ACL, JS, LD, MO, SW and JeD contributed to drafting the text and preparing the figures. For information about the Study Group members and affiliations, see supplementary material.

  • Funding The LIPCAL-ALS study was an investigator-initiated trial of the German ALS/MND network, with institutional support from the German Research Foundation (DFG, grant number LU 336/16-1). Nutricia GmbH (Erlangen, Germany) provided the dietary supplement at a cost reduction of 15%.

  • Competing interests ACL reports that the dietary supplement used in the LIPCAL-ALS study was provided at a cost reduction of 15% by Nutricia GmbH (Erlangen, Germany). All other authors have nothing to report.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Individual participant data that underlie the results reported in this article, after deidentification (text, tables and figures), as well as the study protocol will be available. Data will be available beginning 3 months and ending 5 years following article publication. Data will be shared with researchers who provide a methodologically sound proposal. Data will be shared for analyses to achieve the aims in the approved proposal. Proposals should be directed to; to gain access, data requestors will need to sign a data access agreement. Data are available for 5 years at JoD had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. JeD conducted and is responsible for the data analysis.