Article Text

Download PDFPDF
Amyotrophic Lateral Sclerosis: network vulnerability and monosynaptic connections
  1. Kevin Talbot
  1. Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK
  1. Correspondence to Professor Kevin Talbot, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford OX3 9DU, UK; kevin.talbot{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Does the strength of corticospinal tract input influence the pattern of weakness?

Despite the intense research focus on the molecular and cellular mechanisms of motor neuron degeneration using models based on specific genetic mutations, there are good reasons to consider amyotrophic lateral sclerosis (ALS) as a ‘system degeneration’, which arises through multiple biological triggers. ALS experts generally agree that loss of function has a clinically focal onset and a non-random pattern of spread, which favours the ‘vulnerable network’ hypothesis, in which the degenerative process propagates through compartmentalised anatomical and functional networks.1 Furthermore, evidence from neuropathological studies suggests that the burden of TDP-43 proteinopathy reflects an orderly progression of spread through anatomically contiguous pathways.2 All of which raises the critical question of the nature of the anatomical substrate of …

View Full Text


  • Contributors I am the sole author.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

Linked Articles