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At the dawn of personalised medicine in neuromyelitis optica spectrum disorder: the impact of the disease activity on pregnancy
  1. Norio Chihara
  1. Neurology, Kobe Univerisity, Kobe, Japan
  1. Correspondence to Dr Norio Chihara, Neurology, Kobe Univerisity, Kobe, Japan; chiharan{at}

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A retrospective cohort observation analysing risks of pregnancy-related attacks in neuromyelitis optica spectrum disorder patients

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system characterised by optic neuritis and myelitis, which commonly affects young women of reproductive age. It is also characterised by the production of autoantibodies against aquaporin-4 (AQP4), resulting in the destruction of astrocytes, with a relapse-remitting pattern. NMOSD and multiple sclerosis (MS), which were previously believed the same disease entity, are now being differentiated based on their pathophysiology and treatment responsiveness.1 Since NMOSD predominantly affects young women, pregnancy-related attacks are a major issue for patients.

While the dynamic changes in disease activity during and after pregnancy that are documented for MS, Liang et al provide …

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  • Contributors I wrote this commentary.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

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