Objective To investigate the age-dependent impact of traditional stroke risk factors on the occurrence of intracerebral haemorrhage (ICH).
Methods We performed a case–control analysis, comparing consecutive patients with ICH with age-matched and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) between 2002 and 2014 by multivariable logistic regression model within subgroups stratified by age quartiles (Q1–Q4).
Results We analysed 3492 patients and 3492 controls. The impact of untreated hypertension on the risk of ICH was higher in the lower than in the upper age quartile (OR 11.64, 95% CI 7.68 to 17.63 in Q1 vs OR 6.05, 95% CI 3.09 to 11.85 in Q4 with intermediate ORs in Q2 and Q3), while the opposite trend was observed for untreated hypercholesterolaemia (OR 0.63, 95% CI 0.45 to 0.97 in Q1 vs OR 0.36, 95% CI 0.26 to 0.56 in Q4 with intermediate ORs in Q2 and Q3). The effect of untreated diabetes and excessive alcohol intake was detected only in the older age group (OR 3.63, 95% CI 1.22 to 10.73, and OR 1.69, 95% CI 1.13 to 2.51, respectively).
Conclusions Our findings provide evidence of age-dependent differences in the effects of susceptibility factors on the risk of ICH.
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Contributors ML: study concept and design, acquisition of data, analysis of data, interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content and manuscript submission. MG: study concept and design, acquisition of data and interpretation of data. VS: study concept and design, acquisition of data, interpretation of data and statistical analysis. LI, ADC, GdG, MZ, SM, GS, AC, MLDL, LPC, AG, AZ, MP, MA, CA, ADV, MG, MM, MDS, AT, CG, CF, DMB, RT, GM, AC, AM, SB, VM, DP, AC, RSC, RM, PLS, FG, GT, CL, MR, MC: acquisition of data, critical revision of the manuscript for important intellectual content. APa: acquisition of data, critical revision of the manuscript for important intellectual content. APe: study concept and design, acquisition of data, analysis of data, interpretation of data, drafting of the manuscript, critical revision of the manuscript for important intellectual content, administrative, technical, or material support, study supervision. AP had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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