Article Text

Download PDFPDF
The stage is set for a new trial end point in ALS
  1. Christopher J McDermott
  1. The University of Sheffield, Sheffield, UK
  1. Correspondence to Professor Christopher J McDermott, Department of Neurscience, Sheffield Institute for Translational Neuroscience, The University of Sheffield, Sheffield S10 2HQ, UK; c.j.mcdermott{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Al-Chalabi et al report the findings of a post-hoc analysis of edaravone study 19 to explore the performance of two clinical staging systems.1 2 This interesting work is not intended to settle the efficacy debate around edaravone which requires further prospective studies but it does demonstrate that the information provided by the staging systems may compliment current outcome measures.

The amyotrophic lateral sclerosis functional rating scale - revised (ALSFRS-R) is increasingly being chosen over survival as the primary outcome measure in trials of amyotrophic lateral sclerosis (ALS) to enable faster and smaller trials. This is strategy that is not without its pitfalls as the edaravone situation with patchy worldwide regulatory approval demonstrates; therefore, it is important that the clinical …

View Full Text


  • Contributors CJM is the sole author of the work.

  • Funding This study was supported by National Institute for Health Research and NIHR Sheffield Biomedical Research Centre.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; internally peer reviewed.

Linked Articles