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In patients with melanoma brain metastases and previous intracerebral haemorrhage (ICH), anticoagulation bears a significant risk for clinically symptomatic ICH
Patients with solid malignancies from lung, breast, skin and increasingly from other cancers carry a high risk of developing brain metastases. Particularly with the development of new systemic and personalised medical therapies, the rate of overall survival in these patients is increasing. Patients with cancer, especially those with cerebral involvement, are predisposed to develop venous thromboembolism, requiring therapeutic anticoagulation.1 The application of low-molecular-weighted heparin, warfarin or direct oral anticoagulants (DOACS) presents a risk factor for intralesional and extralesional ICH. ICH may possibly lead to severe neurological impairment, necessity for brain surgery and a consecutive delay of further oncological therapy with impairment of the patient’s …
Contributors Both authors contributed equally in preparing this editorial.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.