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Unilateral cortical FLAIR-hyperintense Lesion in Anti-MOG-associated Encephalitis with Seizures (FLAMES) on TNF inhibitor therapy
  1. Yiu-Chia Chang1,
  2. Manas Sharma2,
  3. Adrian Budhram1,1
  1. 1 Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada
  2. 2 Department of Medical Imaging, Western University, London, Ontario, Canada
  1. Correspondence to Dr Adrian Budhram, Department of Clinical Neurological Sciences, Western University, London N6A 5A5, Canada; Adrian.Budhram{at}lhsc.on.ca

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A 34-year-old man presented with new-onset right-sided headache, episodic visuospatial disorientation and episodic photopsia in his left visual field. His medical history was significant for ulcerative colitis, well-controlled on infliximab 450 mg intravenous every 8 weeks which he had been receiving for the past 10 years. On brain MRI, T1-weighted post-gadolinium imaging revealed right inferior parietal and occipital leptomeningeal enhancement (figure 1A, white circle), with corresponding gyral and sulcal hyperintensity on T2-fluid attenuated inversion recovery (FLAIR) imaging (figure 1B, white circle). No abnormality was seen on T2-weighted or diffusion-weighted imaging (not shown). We suspected focal meningo-encephalitis. Given the concern for an inflammatory central nervous system (CNS) event, infliximab was discontinued. He was trialled on levetiracetam 250 mg PO two times per day for possible focal-onset seizures, but had ongoing episodic photopsia followed by left-sided visual loss 2 weeks later. Neurological examination showed left-sided homonymous hemianopsia. Repeat brain MRI revealed progression of T2-FLAIR hyperintensity involving the right parietal and occipital lobes, with extension to the splenium of the corpus callosum (figure 1C1,C2) and persistent leptomeningeal enhancement (not shown). Repeated cerebrospinal fluid (CSF) …

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Footnotes

  • Contributors AB and Y-CC contributed to conception and design of the study, acquisition and analysis of data, and drafting of the manuscript and figures. MS contributed to acquisition and analysis of data and drafting of the figures.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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