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Does increased microglial activation lead to faster progression in PSP?
  1. Alexander Gerhard
  1. Wolfson Molecular Imaging Centre, Division of Neuroscience and Experimental Psychology, The University of Manchester, Manchester, Manchester, UK
  1. Correspondence to Dr Alexander Gerhard, IBBMH, The University of Manchester, Manchester, Manchester, UK; alex.gerhard{at}

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Subcortical neuroinflammatory changes are associated with faster subsequent clinical progression in PSP

Over the last 20 years, positron emission tomography (PET) with ligands for translocator protein 18 kDa (TSPO) has been increasingly implemented to image microglial activation in neurodegenerative disorders. This PET technique offers the unique possibility of examining ‘neuropathology in vivo’ and correlating the findings with clinical parameters, as well as carrying out longitudinal studies.

Various neurodegenerative disorders have been examined using TSPO PET, leading to different and to some extent conflicting results regarding the role of neuroinflammation and microglial activation.1

Malpetti et al 2 demonstrate in patients with progressive supranuclear …

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  • Contributors AG has authored this commentary.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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