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Frontotemporal lobar degeneration (FTLD) is a complex clinicopathological concept comprising several fatal neurodegenerative diseases. Clinically, behavioural change, language impairment, semantic memory deficits, motor neuron signs, parkinsonism and apraxia can develop in various orders.1 2 Pathologically, tau, transactive response DNA-binding protein 43 kDa and fused in sarcoma are major components of diagnostic lesions of various pathological disease entities. Such clinicopathological complexity may make predicting a longitudinal course difficult in the early stage. On the other hand, most families hope to know the details of the course of a disease and to get practical advice helpful for their life. Researchers also have had a strong interest in this issue.3 4
Murley et al 5 used a transdiagnostic approach to survival in an epidemiological cohort in the UK, examining the association between clinical …
Contributors OY, TM, ST and NY drafted and edited the manuscript.
Funding This work was supported by Grants-in-Aid for Scientific Research (C) from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT KAKENHI grant no. 18K07559), Grants-in-Aid from the Research Committee of CNS Degenerative Diseases and Research on Dementia from the Ministry of Health, Labour and Welfare of Japan (H29-Nanchi-Ippan-033), an Intramural Research Grant for Neurological and Psychiatric Disorders from National Centre of Neurology and Psychiatry (NCNP) (30-8), grants from the Strategic Research Programme for Brain Sciences from Japan Agency for Medical Research and Development (AMED, JP20dm0107109) and grants from Zikei Institute of Psychiatry.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.