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What should we do about vaccination of patients on anti-CD20 antibody therapy?
  1. Takayoshi Shimohata
  1. Department of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan
  1. Correspondence to Professor Takayoshi Shimohata, Neurology, Gifu University, Gifu 501-1194, Japan; shimohata{at}

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The SARS-CoV-2 antibody response was decreased in patients with multiple sclerosis (MS) who were infected with COVID-19 and received anti-CD20 therapy

Vaccination efforts for COVID-19 are currently underway worldwide. At present, there is insufficient evidence of the vaccine’s efficacy and safety in patients with neurological diseases, such as stroke, dementia and intractable neurological diseases. Despite the fact that many patients with neurological diseases are elderly and often have systemic complications, I believe that neurologists should nonetheless actively recommend vaccination to their patients. However, there are at least three problems that I encounter in my daily clinical practice when I vaccinate patients with neurological diseases.

The first problem is that many patients with dementia have no family members or other relatives, and self-determination for vaccination is difficult. The second problem is …

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  • Contributors I am a reviewer of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; internally peer reviewed.

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