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Commonly used outcome measures in neurosurgical trials for major depressive disorder might not capture clinically meaningful treatment effects

Authors

  • Jennifer S Rabin Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Toronto, Ontario, Canada Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Alexander J Nyman Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Benjamin Davidson Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Toronto, Ontario, Canada Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada Division of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Konstantine K Zakzanis Department of Psychology, University of Toronto Scarborough, Toronto, Ontario, Canada Graduate Department of Psychological Clinical Science, University of Toronto Scarborough, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Peter Giacobbe Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Toronto, Ontario, Canada Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Clement Hamani Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Toronto, Ontario, Canada Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada Division of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Sean Nestor Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Toronto, Ontario, Canada Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Nir Lipsman Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Toronto, Ontario, Canada Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada Division of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Jennifer S Rabin, Harquail Centre for Neuromodulation, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada; jennifer.rabin{at}sri.utoronto.ca
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Citation

Rabin JS, Nyman AJ, Davidson B, et al
Commonly used outcome measures in neurosurgical trials for major depressive disorder might not capture clinically meaningful treatment effects

Publication history

  • Received July 24, 2021
  • Accepted December 16, 2021
  • First published January 25, 2022.
Online issue publication 
March 14, 2022

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