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Microstructural changes in the normal appearance cerebral cortex of multiple sclerosis detected by an advanced diffusion MRI technique
  1. Atsuhiko Sugiyama,
  2. Satoshi Kuwabara
  1. Neurology, Chiba University Graduate School of Medicine, Chiba, Japan
  1. Correspondence to Dr Atsuhiko Sugiyama, Neurology, Chiba University Graduate School of Medicine School of Medicine, Chiba, Chiba, Japan; asugiyama{at}

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An advanced diffusion MRI shows new aspects of the normal appearance cortical abnormalities in patients with multiple sclerosis (MS).

Preziosa et al report on microstructural abnormalities observed in MS1 and specifically describe normal-appearing cortex and cortical lesions assessed in vivo using neurite orientation dispersion and density imaging (NODDI), an advanced diffusion MRI technique. The study included a large cohort of 172 patients with MS (101 relapsing-remitting, 71 progressive) and 62 healthy controls. They found that normal-appearing cortex in MS was characterised by a decreased intracellular volume fraction (ICV_f), which is more evident in cortical lesions. Because ICV_f is correlated with neurite density, these findings suggest that a significant …

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  • Contributors AS drafted the text, and SK supervised and made revisions.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.

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