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132  Thymectomy for myasthenia gravis in the West of Scotland: a retrospective study
  1. Valentina Fenech1,
  2. Alan Kirk2,
  3. Caroline Carmichael3,
  4. Maria Elena Farrugia3
  1. 1Department of Medicine, Royal Alexandra Hospital, Glasgow
  2. 2Department of Cardiothoracic Surgery, Golden Jubilee National Hospital, Glasgow
  3. 3Department of Neurology, Queen Elizabeth University Hospital, Glasgow

Abstract

The international thymectomy trial (MGTX) demonstrated benefits in myasthenia gravis (MG) patients without thymoma and up to the age of 65 years. This data and the increased availability of minimally invasive thymectomy surgery has resulted in an increasing number of patients being referred for thymec- tomy. We evaluated the clinical outcomes after thymectomy in 61 MG patients with or without thymic epithelial tumours (TET) from the West of Scotland Myasthenia database over a 10-year period.

All patients had positive acetylcholine receptor antibodies. Twenty-five (41%) patients were male. Fifty-five (90.2%) had generalised MG (27 patients with TET [TET-MG], all thymoma except for one with squamous cell thymic carcinoma; 28 patients without TET [non-TET-MG]) and 6 (9.8%) had ocular MG (including 3 TET-MG patients with thymoma). Overall, age at onset and diagnosis were comparable, with a lower median age at onset for female MG patients without TET. More severe symptoms at onset and at nadir were noted in TET-MG patients.

MGFA-post intervention status was similar in both groups, although more MG relapses were observed in the TET-MG group. TET-MG patients had slightly worse disease severity and outcomes. However, the two groups were largely comparable in their MG status and the therapies they received.

vally fenech@gmail.com

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