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  • Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

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Neurodegeneration
Original research
Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Authors

  • Katherine M Wilson UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Eszter Katona UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Idoia Glaria UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Mireia Carcolé UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Imogen J Swift UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Aitana Sogorb-Esteve UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Carolin Heller UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Arabella Bouzigues Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Amanda J Heslegrave UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Ashvini Keshavan Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Kathryn Knowles UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Saurabh Patil Wave Life Sciences, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Susovan Mohapatra Wave Life Sciences, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Yuanjing Liu Wave Life Sciences, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Jaya Goyal Wave Life Sciences, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Raquel Sanchez-Valle Alzheimer’s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d’Investigacións Biomèdiques August Pi I Sunyer, University of Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Robert Jr Laforce Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, CHU de Québec, and Faculté de Médecine, Université Laval, Quebec City, Quebec, Canada PubMed articlesGoogle scholar articles
  • Matthis Synofzik Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany Center for Neurodegenerative Diseases, (DZNE), Tübingen, Germany PubMed articlesGoogle scholar articles
  • James B Rowe Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust and Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Elizabeth Finger Department of Clinical Neurological Sciences, University of Western Ontario, University of Western Ontario, London, Ontario, Canada PubMed articlesGoogle scholar articles
  • Rik Vandenberghe Leuven Brain Institute, KU Leuven, Leuven, Belgium Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium Neurology Service, University Hospitals, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Christopher R Butler Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK Department of Brain Sciences, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  • Alexander Gerhard Division of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, UK Departments of Geriatric Medicine and Nuclear Medicine, University of Duisburg- Essen, University of Duisburg- Essen, Essen, Germany PubMed articlesGoogle scholar articles
  • John C Van Swieten Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands PubMed articlesGoogle scholar articles
  • Harro Seelaar Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands PubMed articlesGoogle scholar articles
  • Barbara Borroni Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy PubMed articlesGoogle scholar articles
  • Daniela Galimberti Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy Centro Dino Ferrari, University of Milan, Milan, Italy PubMed articlesGoogle scholar articles
  • Alexandre de Mendonça Faculty of Medicine, University of Lisbon, Lisbon, Portugal PubMed articlesGoogle scholar articles
  • Mario Masellis Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • M Carmela Tartaglia Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada Canadian Sports Concussion Project, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Markus Otto Department of Neurology, University of Ulm, Ulm, Germany PubMed articlesGoogle scholar articles
  • Caroline Graff Center for Alzheimer Research, Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Bioclinicum, Karolinska Institutet, Solna, Sweden Unit for Hereditary Dementias, Theme Aging, Karolinska University Hospital, Solna, Sweden PubMed articlesGoogle scholar articles
  • Simon Ducharme McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • Jonathan M Schott Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Andrea Malaspina Barts and The London School of Medicine and Dentistry Blizard Institute, London, UK UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK PubMed articlesGoogle scholar articles
  • Henrik Zetterberg UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden PubMed articlesGoogle scholar articles
  • Ramakrishna Boyanapalli Wave Life Sciences, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Jonathan D Rohrer UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK PubMed articlesGoogle scholar articles
  • Adrian M Isaacs UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK PubMed articlesGoogle scholar articles
  • on behalf of the Genetic FTD Initiative (GENFI)
    Google scholar articles
  1. Correspondence to Dr Adrian M Isaacs, UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, London, UK; a.isaacs{at}ucl.ac.uk
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Citation

Wilson KM, Katona E, Glaria I on behalf of the Genetic FTD Initiative (GENFI), et al
Development of a sensitive trial-ready poly(GP) CSF biomarker assay for C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
Journal of Neurology, Neurosurgery & Psychiatry 2022;93:761-771.

Publication history

  • Received December 21, 2021
  • Accepted March 4, 2022
  • First published April 4, 2022.
Online issue publication 
July 13, 2022

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.