Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial

Sabrina Paganoni; Suzanne Hendrix; Samuel P Dickson; Newman Knowlton; James D Berry; Michael A Elliott; Samuel Maiser; Chafic Karam; James B Caress; Margaret Ayo Owegi; Adam Quick; James Wymer; Stephen A Goutman; Daragh Heitzman; Terry D Heiman-Patterson; Carlayne Jackson; Colin Quinn; Jeffrey D Rothstein; Edward J Kasarskis; Jonathan Katz; Liberty Jenkins; Shafeeq S Ladha; Timothy M Miller; Stephen N Scelsa; Tuan H Vu; Christina Fournier; Kristin M Johnson; Andrea Swenson; Namita Goyal; Gary L Pattee; Suma Babu; Marianne Chase; Derek Dagostino; Meghan Hall; Gale Kittle; Mathew Eydinov; Joseph Ostrow; Lindsay Pothier; Rebecca Randall; Jeremy M Shefner; Alexander V Sherman; Eric Tustison; Prasha Vigneswaran; Hong Yu; Joshua Cohen; Justin Klee; Rudolph Tanzi; Walter Gilbert; Patrick Yeramian; Merit Cudkowicz

doi:10.1136/jnnp-2022-329024

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Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial

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Sabrina Paganoni Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA Department of PM & R, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts, USA PubMed articles Google scholar articles
Suzanne Hendrix Pentara Corporation, Millcreek, Utah, USA PubMed articles Google scholar articles
Samuel P Dickson Pentara Corporation, Millcreek, Utah, USA PubMed articles Google scholar articles
Newman Knowlton Pentara Corporation, Millcreek, Utah, USA PubMed articles Google scholar articles
James D Berry Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Michael A Elliott Swedish Neuroscience Institute, Seattle, Washington, USA PubMed articles Google scholar articles
Samuel Maiser Department of Neurology, Hennepin Healthcare, Minneapolis, Minnesota, USA PubMed articles Google scholar articles
Chafic Karam Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
James B Caress Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA PubMed articles Google scholar articles
Margaret Ayo Owegi Department of Neurology, University of Massachusetts Memorial Medical Center, Worcester, Massachusetts, USA PubMed articles Google scholar articles
Adam Quick Department of Neurology, Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
James Wymer Department of Neurology, College of Medicine, University of Florida, Gainesville, Florida, USA PubMed articles Google scholar articles
Stephen A Goutman Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Daragh Heitzman ALS Clinic, Texas Neurology, Dallas, Texas, USA PubMed articles Google scholar articles
Terry D Heiman-Patterson Department of Neurology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Carlayne Jackson Department of Neurology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA PubMed articles Google scholar articles
Colin Quinn Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Jeffrey D Rothstein Department of Neurology, Johns Hopkins University Brain Science Institute, Baltimore, Maryland, USA PubMed articles Google scholar articles
Edward J Kasarskis Department of Neurology, University of Kentucky, Lexington, Kentucky, USA PubMed articles Google scholar articles
Jonathan Katz California Pacific Medical Center Research Institute and Forbes Norris MDA/ALS Research and Treatment Center, San Francisco, California, USA PubMed articles Google scholar articles
Liberty Jenkins California Pacific Medical Center Research Institute and Forbes Norris MDA/ALS Research and Treatment Center, San Francisco, California, USA PubMed articles Google scholar articles
Shafeeq S Ladha Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA PubMed articles Google scholar articles
Timothy M Miller Hope Center for Neurological Disorders, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA PubMed articles Google scholar articles
Stephen N Scelsa Department of Neurology, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, New York, USA PubMed articles Google scholar articles
Tuan H Vu Department of Neurology, University of South Florida Morsani College of Medicine, Tampa, Florida, USA PubMed articles Google scholar articles
Christina Fournier Department of Neurology, Emory University, Atlanta, Georgia, USA PubMed articles Google scholar articles
Kristin M Johnson Department of Neurology, Ochsner Health System, New Orleans, Louisiana, USA PubMed articles Google scholar articles
Andrea Swenson Department of Neurology, University of Iowa Health Care, Iowa City, Iowa, USA PubMed articles Google scholar articles
Namita Goyal Department of Neurology, University of California Irvine School of Medicine, Irvine, California, USA PubMed articles Google scholar articles
Gary L Pattee Neurology Associates, Lincoln, Nebraska, USA PubMed articles Google scholar articles
Suma Babu Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Marianne Chase Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Derek Dagostino Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Meghan Hall Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA PubMed articles Google scholar articles
Gale Kittle Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA PubMed articles Google scholar articles
Mathew Eydinov Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Joseph Ostrow Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Lindsay Pothier Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Rebecca Randall Worldwide Clinical Trials, Research Triangle Park, North Carolina, USA Formerly With Gregory W. Fulton ALS Center, Barrow Neurological Institute, Phoenix, Arizona, USA PubMed articles Google scholar articles
Jeremy M Shefner Department of Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA PubMed articles Google scholar articles
Alexander V Sherman Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Eric Tustison Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Prasha Vigneswaran Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Hong Yu Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Joshua Cohen Amylyx Pharmaceuticals Inc, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Justin Klee Amylyx Pharmaceuticals Inc, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Rudolph Tanzi Department of Neurology, Genetics and Aging Research Unit, McCance Center for Brain Health, Massachusetts General Hospital, Harvard University, Boston, Massachusetts, USA PubMed articles Google scholar articles
Walter Gilbert Carl M. Loeb University Professor Emeritus and Chair of the Society of Fellows at Harvard, Harvard University, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Patrick Yeramian Amylyx Pharmaceuticals Inc, Cambridge, Massachusetts, USA PubMed articles Google scholar articles
Merit Cudkowicz Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles

Correspondence to Dr Sabrina Paganoni, Harvard Medical School, Sean M. Healey and AMG Center for ALS & the Neurological Clinical Research Institute, Massachusetts General Hospital, Boston, Massachusetts, USA; spaganoni{at}mgh.harvard.edu

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Paganoni S, Hendrix S, Dickson SP, et al

Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial

Journal of Neurology, Neurosurgery & Psychiatry 2022;93:871-875.

Publication history

Received February 8, 2022
Accepted March 23, 2022
First published May 16, 2022.

Online issue publication

May 22, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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