You are here

Article Text

Article menu
Download PDFPDF
ABN Abstracts 2022
Parallel Session 5: MS and neuroinflammation| Fri 20 May, 1130 – 1245|2
Longitudinal clinical study of patients with white matter iron rims lesions in multiple sclerosis
  1. Amjad Altokhis1,2,3,
  2. Aimee Hibbert2,
  3. Christopher Allen1,2,
  4. Olivier Mougin4,
  5. Abdulmajeed Alotaibi1,2,5,
  6. Su-Yin Lim1,6,
  7. Cris Constantinescu7,
  8. Rasha Abdel-Fahim2,
  9. Nikos Evangelou1,2
  1. 1Mental and Clinical Neuroscience Academic unit, University of Nottingham
  2. 2Department of Neurology, Nottingham University Hospital NHS Trust
  3. 3Division of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh
  4. 4Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham
  5. 5Department of Radiological Sciences, School of Applied Medical Sciences, King Saud bin Abdul-Aziz Un
  6. 6School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Malaysia
  7. 7Department of Neurology, Cooper Neurology Institute, Camden, USA

Abstract

Introduction Identifying accurate prognostic imaging biomarkers in multiple sclerosis (MS) is crucial. Iron rims (IR) surrounding white matter lesions (WML) are suggested to predict a more severe disease course. Only small longitudinal cohorts of patients with and without IRL have been reported so far.

Objective To assess if the presence and number of IRL in patients with CIS and MS are associated with worse long-term clinical disability.

Methods Ninety-one CIS/MS patients were recruited between 2008 and 2013 and scanned with 7T MRI. Age-Related Multiple Sclerosis Score (ARMSS), a validated measure of disease severity, was calculated for patients at the time of scan and at the latest clinical follow-up after 9 years. WMLs were assessed for the presence of IRL using SWI-filtered phase images.

Results 132 IRLs were detected in 42 patients (46%). 9% of WMLs had IR. 54% of the cohort had no rims, 30% had 1-3 rims and 16% had ≥4. Patients with IRL at baseline had a higher EDSS and ARMSS. Presence of IRL was also a predictor of long-term disability especially in those patients with ≥4 IRL. The effect of IRL on disability was greater than the baseline WML numbers, another known prognostic biomarker.

Conclusion The presence and number of perilesional IR at a baseline scan hold prognostic value for long term clinical disability in MS.

https://doi.org/10.1136/jnnp-2022-abn2.27

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.