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ABN Abstracts 2022
Poster presentations
096 Motor and non-motor features of prodromal Parkinson’s in idiopathic anosmia
  1. Richard Rees1,2,
  2. Carl Philpot3,4,
  3. Simon Gane5,
  4. Lisha McLelland6,
  5. Aneet Gill7,
  6. Gavin Giovannoni8,
  7. Cris- tina Simonet7,
  8. Andrew Lees2,
  9. Alastair Noyce2,7,
  10. Anette Schrag2
  1. 1St George’s University Hospital
  2. 2Department of Clinical and Movement Neuroscience, Institute of Neurology, UCL
  3. 3Rhinology and ENT Research Group, Norwich Medical School
  4. 4James Paget Hospital, Norfolk
  5. 5Rhinology Section, Royal National ENT Hospital, London
  6. 6Department of Otolaryngology, University Hospitals Birmingham
  7. 7Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Barts and the London
  8. 8Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University, London

Abstract

Introduction Anosmia is common at the point of diagnosis of Parkinson’s disease (PD) and often predates motor symptoms. Other non-motor symptoms are also recognised to predate overt motor impairment in PD.

Objective To identify prodromal markers of PD in patients with idiopathic anosmia (IA).

Methods Patients age >55y diagnosed with IA in sub-specialist ENT clinics were recruited to the PREDICT-PD study. We compared them with lower-risk healthy older adults (HA) in PREDICT-PD and PD patients. Par- ticipants were assessed with MDS-UPDRS I-III, as well as standardised assessments of cognition, autonomic function, pain and sleep. The IA group were split into those with mild motor impairment (IA-MMI) and normal motor function (IA-NM), and the comparisons repeated.

Results We recruited 28 HA, 42 IA and 21 PD. The groups were well matched for age and gender. Compared with HA, IA had worse sleep (PD Sleep Scale p=0.023), depressive symptoms (HADS p=0.03) and gastrointestinal (GI) symptoms (SCOPA-AUT GI p=0.035). 23.8% of IA and 15.0% HA scored >6 on the MDS-UPDRS III (p=0.29). IA-NM did not differ from IA-MMI in any domain, including functional motor tasks.

Conclusion Participants with IA did not have demonstrable impairments in motor or non-motor tests when compared to healthy older adults, with the exception of sleep, mood and GI symptoms.

https://doi.org/10.1136/jnnp-2022-abn2.140

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