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H44 Impact of cognition, motor function and depression on quality of life in patients with Huntington’s disease
  1. Kristina Cubel1,
  2. Antonia Meyer2,
  3. Peter Fuhr2,
  4. Ute Gschwandtner2
  1. 1Felix Platter Spital, Basel, Switzerland
  2. 2Universitätsspital Basel, Basel, Switzerland

Abstract

Background Huntington’s disease (HD) has a significant impact on the Quality of Life (QoL) of the afflicted patients. However relatively few studies have been conducted to determine the most pertinent factors.

Aims To analyse the impact of cognitive, motor, and emotional status on QoL measured by HD-Pro-Triad (Carlozzi 2014), HD-QoL (Hocaoglu 2012), and BDI (Beck 1961).

Methods/Techniques 11 patients (4 female) with genetically proven HD. Age mean = 56.9 (± 10.7 years), Education mean = 12.2 (± 3.3 years) were analysed by UHDRS (Kleturtz 1996), HD-Pro-Triad, HD-QoL and BDI with the goal to determine whether cognition, motor function, or depression has the highest influence on QoL. Statistical analyses were conducted with Shapiro-Wilks-Test and Spearman Rank correlation, (p < 0.05) was regarded as significant.

Results/Outcome We found a significant inter-correlation between motor function, cognitive status, and depression (p < 0.05). Stepwise regression analyses revealed motor function (p < 0.01) and female gender (p < 0.05) as significant predictors for QoL of HD-patients.

Conclusions There might be a common factor dominated by motor deficits influencing QoL of HD-patients, which should be analysed in a larger sample with e.g. a factor analytic method.

  • Huntington’s disease
  • Motor function
  • QoL
  • Cognition
  • Depression

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