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  • Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial

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Epilepsy
Original research
Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial

Authors

  • Kensuke Nakamura Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki, Japan Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • Aiki Marushima Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan Division of Stroke prevention and treatment, Department of Neurosurgery, Faculty of Medicine,University of Tsukuba, Tsukuba, Ibaraki, Japan Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan Epilepsy Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • Yuji Takahashi Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • Masaki Mochizuki Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • Akio Kimura Department of Emergency Medicine and Critical Care, National Center for Global Health and Medicine, Toyama Shinjuku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Yu Fukuda Department of Emergency Medicine and Critical Care, National Center for Global Health and Medicine, Toyama Shinjuku, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Masahiro Asami Department of Emergency Medicine, Teikyo University Hospital, Itabashi, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Hidetoshi Nakamoto Neurointensive Care Unit, Neurosurgery, Stroke and Epilepsy Center, TMG Asaka Medical Center, Asaka, Saitama, Japan PubMed articlesGoogle scholar articles
  • Satoshi Egawa Neurointensive Care Unit, Neurosurgery, Stroke and Epilepsy Center, TMG Asaka Medical Center, Asaka, Saitama, Japan PubMed articlesGoogle scholar articles
  • Junya Kaneko Department of Emergency and Critical Care Medicine, Nippon Medical School Tama Nagayama Hospital, Tama, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Kyoko Unemoto Department of Emergency and Critical Care Medicine, Nippon Medical School Tama Nagayama Hospital, Tama, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Yutaka Kondo Department of Emergency and Critical Care Medicine, Juntendo University Urayasu Hospital, Urayasu, Chiba, Japan PubMed articlesGoogle scholar articles
  • Chikara Yonekawa Department of Emergency and Critical Care Medicine, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan PubMed articlesGoogle scholar articles
  • Masatoshi Uchida Emergency and Critical Care Medical Center, Dokkyo Medical University, Shimotsuga, Tochigi, Japan PubMed articlesGoogle scholar articles
  • Eisei Hoshiyama Emergency and Critical Care Medical Center, Dokkyo Medical University, Shimotsuga, Tochigi, Japan PubMed articlesGoogle scholar articles
  • Takeshi Yamada Tsukuba Clinical Research and Development Organization (T-CReDO), University of Tsukuba, Tsukuba, Ibaraki, Japan Department of Biostatistics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • Kazushi Maruo Department of Biostatistics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • Eiichi Ishikawa Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan Epilepsy Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • Yuji Matsumaru Division of Stroke prevention and treatment, Department of Neurosurgery, Faculty of Medicine,University of Tsukuba, Tsukuba, Ibaraki, Japan Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • Yoshiaki Inoue Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan Epilepsy Center, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan PubMed articlesGoogle scholar articles
  • IENE ECT with the LIFE study group
    Google scholar articles
  1. Correspondence to Dr Aiki Marushima, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; aiki.marushima{at}md.tsukuba.ac.jp
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Citation

Nakamura K, Marushima A, Takahashi Y IENE ECT with the LIFE study group, et al
Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial
Journal of Neurology, Neurosurgery & Psychiatry 2023;94:42-48.

Publication history

  • Received April 21, 2022
  • Accepted August 5, 2022
  • First published October 7, 2022.
Online issue publication 
May 17, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.