Footnotes

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• Contributors JDR and EHSD-T designed the study, analysed the data and wrote the manuscript. TR analysed the pathological data and reviewed the manuscript. ET, RC, MB, MC, JDW and NCF helped with data collection, analysis and review of the manuscript.

• Funding The Dementia Research Centre is supported by Alzheimer's Research UK, Alzheimer's Society, Brain Research UK, and The Wolfson Foundation. This work was supported by the NIHR UCL/H Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility, and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society and Alzheimer's Research UK. JDR is supported by the Miriam Marks Brain Research UK Senior Fellowship and has received funding from an MRC Clinician Scientist Fellowship (MR/M008525/1) and the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). JDW is supported by the Alzheimer’s Society and by the NIHR UCLH Biomedical Research Centre. NCF is supported by the NIHR UCL/H Biomedical Research Centre and the UK Dementia Research Institute, which receives its funding from DRI Ltd, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK.

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.