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Evidence of a third branch in the uncinate fasciculus and possible implications
  1. Ester di Giacomo1,
  2. Biagio Eugenio Leone2,
  3. Massimo Clerici3,
  4. Fabio Grassia4
  1. 1 University of Milan-Bicocca, Milano, Italy
  2. 2 University of Milano Bicocca, Milan, Italy
  3. 3 University of Milan-Bicocca Faculty of Medicine and Surgery, Monza, Italy
  4. 4 Department of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado, USA
  1. Correspondence to Dr Ester di Giacomo, University of Milan-Bicocca, Milano, Lombardia 38-20900, Italy; ester.digiacomo{at}

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The uncinate fasciculus (UF) is a ventral, anterior, associative C-shaped white matter bundle that connects the temporo-amygdala-orbitofrontal network, which is functionally dedicated to the integration of visceral and emotional states, cognition and behaviour.1 Issues in that network are shown with cognitive and behavioural symptoms characteristic of temporal lobe epilepsy, mood disorders and neurodegenerative dementias, including Alzheimer’s disease and semantic dementia. In animal studies, the disconnection of the UF causes impairment of object–reward association and learning temporally complex visual …

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  • Twitter @ester_digiacomo

  • Contributors EdG planned this reasearch, collected data and wrote this report. BEL and FG collected data. EdG, FG and MC supervised work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.