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Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis
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  • Published on:
    Correspondence on "Prognostic value of spinal cord lesion measures in early relapsing-remitting multiple sclerosis"
    • Ali Mirshamsi, MD Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

    I recently had the opportunity to read your article titled "Prognostic Value of Spinal Cord Lesion Measures in Early Relapsing-Remitting Multiple Sclerosis" [1] and I want to extend my appreciation for the significant contribution your research has made to the field of multiple sclerosis (MS). Your study investigated the relation of whole spinal cord lesion number (SCLN) and volume (SCLV) to the future occurrence and type of confirmed disability accumulation (CDA) in patients with relapsing-remitting MS. The manual delineation of SC lesions and the subsequent analyses provided valuable insights into the prospective value of these measures in predicting clinical outcomes. The significant association between the absence of SC lesions and reduced CDA risk suggests the importance of SC lesions as a prognostic indicator in MS. Additionally, the close correlation between SCLN and SCLV, and their independent association with CDA, provide further support for the relevance of these measures in predicting disability accumulation.
    The classification of CDA events into progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) facilitated a nuanced analysis of their association with SC lesion measures. The significant association with PIRA, but not RAW, hints at distinct underlying mechanisms for different types of disability progression, which could have implications for treatment strategies.
    While your study provides valuable insi...

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    Conflict of Interest:
    None declared.