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Multiple sclerosis
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Childbirth delivery mode and the risk of multiple sclerosis: a prospective population-based study
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  • Published on: 14 December 2023
    The association between childbirth delivery mode and development of multiple sclerosis
    • Poorya Kheyrandish, MD Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran

    Dear Editor,
    I am writing to express my appreciation for the enlightening article titled "Childbirth Delivery Mode and the Risk of Multiple Sclerosis: A Prospective Population-Based Study" [1] recently published in your esteemed journal. The study, which examines the potential relationship between childbirth mode and the subsequent risk of multiple sclerosis (MS) development, presents a comprehensive analysis and incites intriguing discussions. The authors embarked on a commendable endeavor by conducting a meticulous prospective cohort study encompassing individuals born in Norway between 1967 and 2003. Their investigation aimed to unravel the potential influence of caesarean section (CS) births on the risk of adult-onset MS. The findings unveil an association suggesting an 18% elevated risk of MS among individuals born via CS, as compared to those born vaginally, after considering an array of confounding factors. However, the authors astutely highlight that this association does not persist when a sibling-matched analysis is undertaken. Furthermore, this intriguing connection appears to be primarily confined to individuals born preterm or via emergency CS. Such nuanced insights underline the complexities underlying the childbirth mode and MS risk paradigm, necessitating a thoughtful interpretation of the findings.
    The authors acknowledge the divergent findings from previous studies, emphasizing the discrepancies between their results and those report...

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    Conflict of Interest:
    None declared.