Biopsy findings in Parry Romberg Syndrome / Scleroderma 'en coup de sabre'

Jon Stone, Consultant Neurologist,
September 27, 2010

Moseley et al report an interesting case of Parry Romberg syndrome with contralateral MRI changes. A similar case of Scleroderma 'en coup de sabre' was published previously in JNNP. This case also had a brain biopsy of a contralateral thalamic lesion and similar perivascular inflammatory changes were seen [1].

Reports of neuropathology remain rare in these overlap conditions. This additional report is useful in improving confidence in the hypothesis that they are fundamentally neuroinflammatory disorders.

1. Stone J, Guthrie A, Franks A, Johnson MH. Scleroderma "en coup de sabre": pathological evidence of intracerebral inflammation. Journal of Neurology, Neurosurgery and Psychiatry 2001;70:382-385.

Conflict of Interest:

None declared

Conflict of Interest

None declared