Article Text

other Versions

Download PDFPDF
Cerebrospinal fluid Aβ42 concentration may predict cognitive decline in elderly women
  1. Deborah R Gustafson (deb.gustafson{at}
  1. Göteborg University, Sweden
    1. Ingmar Skoog (ingmar.skoog{at}
    1. Göteborg University, Sweden
      1. Lars Rosengren (lars.rosengren{at}
      1. Göteborg University, Sweden
        1. Henrik Zetterberg (henrik.zetterberg{at}
        1. Goteborg University, Sweden
          1. Kaj Blennow (kaj.blennow{at}
          1. Goteborg University, Sweden


            Background: Low levels of cerebrospinal fluid (CSF) β-amyloid 1-42 (Aβ42) and high total tau (T-tau) are diagnostic for manifest Alzheimer’s disease. It is not known however, whether these biomarkers may be risk indicators for cognitive decline in otherwise healthy elderly.

            Methods: We investigated the longitudinal relationship between CSF markers, β-amyloid 1-42 (Aβ42) and total tau (T-tau), measured in 1992, and change in Mini-Mental State Examination (ΔMMSE) score between 1992 and 2000-2002. This was accomplished in 55 women (age 70-84 years, mean MMSE score = 28.3 +/- 1.5), who were participants in the Prospective Population Study of Women in Gothenburg, Sweden. These women were not demented when they experienced lumbar puncture in 1992.

            Results: Over the 8-year follow-up period, ΔMMSE (range= +3 to -21 points) was correlated with Aβ42 (Spearman’s r=0.404, p=0.002), such that lower levels of Aβ42 were related to greater decline. This was also observed after excluding 4 women who developed dementia between 1992 and 2002 (Spearman’s r=0.338, p=0.019). A multivariate logistic regression model predicting decline of 5 or more points on the MMSE (observed in 6 women) or becoming demented over the 8 year follow-up period (observed in 4 women), and including age, education, Aβ42, and T-tau, and showed that Aβ42 was the sole predictor of significant cognitive decline or dementia (OR per 100 pg/ml=2.24 95% CI 1.19-4.22, p=0.013).

            Conclusions: Low levels of CSF Aβ42 may predict cognitive decline among elderly women without dementia.

            • Alzheimer
            • amyloid-beta protein
            • biological marker
            • cognition
            • tau

            Statistics from

            Request Permissions

            If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.