Article Text

other Versions

Download PDFPDF
Torsional deviations with voluntary saccades due to a unilateral midbrain lesion
  1. Olympia Kremmyda (olkrem{at}
  1. Ludwig Maximilians University, Klinikum Grosshadern, Germany
    1. Jean A. Buttner-Ennever (buettner{at}
    1. Ludwig-Maximilians University Munich, Institute of Anatomy, Germany
      1. Ulrich Buttner (ulrich.buettner{at}
      1. Ludwig Maximilians University, Klinikum Grosshadern, Germany
        1. Stefan Glasauer (s.glasauer{at}
        1. Ludwig-Maximilians University Munich, Germany


          Three-dimensional eye rotations were measured using the magnetic search coil technique, in a patient with a right rostral interstitial nucleus of the medial longitudinal fasciculus (RIMLF) lesion and four control subjects. Up to 10 deg contralesional torsional deviations with each voluntary saccade were revealed, which also could be seen during bedside examination. There was no spontaneous nystagmus. Based on MRI criteria the lesion involved RIMLF but spared the interstitial nucleus of Cajal (INC). This deficit has so far not been described in patients. Our results also support the hypothesis that the vertical-torsional saccade generator in humans is organized similarly as in monkeys: each RIMLF encodes torsional saccades in one direction, while both participate in vertical saccades.

          • RIMLF
          • burst generator
          • eye torsion

          Statistics from

          Request Permissions

          If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

          Supplementary materials