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Short report
Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration
Abstract
We applied optimised voxel based morphometry (VBM) to brain MRIs from autopsy proven cases of tau positive frontotemporal lobar degeneration (FTLD-T, n = 6), ubiquitin and TDP-43 positive/tau negative FTLD (FTLD-U, n = 8) and cognitively normal controls (n = 61). The analysis revealed that FTLD-T and FTLD-U both show atrophy in the frontal cortex and striatum, but striatal atrophy is more severe in FTLD-T. Manual region of interest tracing of caudate and putamen volumes confirmed the VBM findings. These anatomical differences may help distinguish between FTLD spectrum pathological subtypes in vivo.
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Footnotes
Competing interests: None.
- Abbreviations:
- FTLD
- frontotemporal lobar degeneration
- FTLD-T
- tau positive frontotemporal lobar degeneration
- FTLD-U
- ubiquitin and TDP-43 positive/tau negative frontotemporal lobar degeneration
- MAC
- Memory and Aging Center
- MMSE
- Mini Mental State Examination
- VBM
- voxel based morphometry