Article Text

other Versions

Neurological care and risk of hospital mortality for patients with myasthenia gravis in England
  1. Marguerite Hill (marguerite{at}
  1. Univesity of Bristol, United Kingdom
    1. Yoav Ben-Shlomo (y.ben-shlomo{at}
    1. University of Bristol, United Kingdom


      Background: Myasthenia gravis (MG) is a rare neurological disorder, which can be life threatening. Though death is a rare outcome, evidence does not exist as to whether neurological care leads to any better outcome than care by other specialties.

      Methods: A matched nested case control study sampled from all public sector hospital admissions in England with a primary diagnosis of myasthenia gravis from 1991-1999. Cases were defined as MG admissions which resulted in death and controls were other MG admissions, matched on sex, age (+/- 2 years) and date of admission (+/- 20 days) that were non fatal. From a total of 18,251 finished consultant episodes with a mention of MG, we were able to create 196 matched sets with 196 fatal admissions and 788 control admissions.

      Results: Admission under a neurologist was associated with a 69% reduced risk of death (odds ratio 0.31, 95% CI 0.22 to 0.44, p<0.0001). This was only slightly attenuated after adjustment for a variety of patient-related and hospital covariates (odds ratio 0.37, 95% CI 0.23 to 0.62, p<0.0001).

      Conclusions: This is the first evidence that patients admitted with MG are far less likely to die if they are under the care of a neurologist. We cannot determine whether this is due to better management per se or because neurologists are usually based in specialist centres and may have better intensive care support, or both. Alternatively, this may be due to “selection bias” so that neurologists select less seriously ill patients.

      • case control study
      • mortality
      • myasthenia gravis
      • specialist care

      Statistics from

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.