The relevance of gluten sensitivity in hereditary ataxia pathogenesis is unclear. Objective: To evaluate the significance of antigliadin antibodies levels for spinocerebellar ataxia type 2. Methods: We determined antigliadin antibodies in 64 spinocerebellar ataxia type 2 patients and in 65 healthy matched controls. The clinical assessment was carried out using the International Cooperative Ataxia Rating Scale and CAG repeat number was assessed by PCR. Results: Antibodies were positive in 23,4% of the ataxia patients and 9,09% of the controls. Statistical comparison using (chi)2 test with Yates’s correction reveal significant differences between these two groups (?2 = 3,94; p= 0,047). The same was obtained for strongly positive antigliadin antibodies (?2 = 4,62; p= 0,032). There were not significant differences between AGA positive and AGA negative patients in age at onset, disease duration, ataxia score, or CAG repeat number; neither in the prevalence of gastrointestinal symptoms, prevalence of wheat intolerance, or body weight. These results demonstrates an association between antigliadin antibodies serum levels and SCA2. However, more work has to be done to clarify the clinical consequences of such an association.
- Antigliadin antibodies
- Gluten sensitivity
- Spinocerebellar ataxia type 2
- polyglutamine proteins
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