Objective: To determine the risk of cancer before and after the diagnosis of motor neuron disease (MND), multiple sclerosis (MS), and Parkinson’s disease (PD).
Methods: Analysis of statistical database of linked statistical abstracts of hospital and mortality data in an area in southern England.
Results: Only people with PD showed a significant difference in the overall incidence of cancer compared to controls (rate ratio (RR) 0.76, 95 % confidence intervals 0.70-0.82 before PD; RR 0.61, 0.53-0.70, after PD). Rate ratios were close to one for cancer in patients after MND (0.98, 0.75-1.26) and after MS (0.96, 0.83-1.09). There were high rate ratios for malignant brain cancer (RR 7.4, 2.4-17.5) and Hodgkin’s lymphoma (5.3, 1.1-15.6) in patients diagnosed with MND after cancer. In people with MS, malignant brain cancer also showed an increased rate ratio both before hospital admission with a diagnosis of MS (RR 3.2, 1.1-7.6) and after (RR 2.4, 1.2-4.5). In people with PD, several specific cancers showed significantly and substantially reduced rate ratios for cancer, notably smoking-related cancers including lung cancer (RR 0.5, 0.4-0.7, before PD; 0.5, 0.4-0.8, after PD) but also cancers that are not strongly smoking-related including colon cancer (RR 0.7, 0.6-0.9, before PD; 0.5, 0.4-0.8, after PD).
Conclusions: People with MND, or MS, do not have an altered risk of cancer overall. There may sometimes be misdiagnosis between MND or MS and brain tumours. PD carries a reduced risk of cancer overall, of some smoking-related cancers, and of some cancers that are not smoking-related.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.