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Magnesium and headache after aneurysmal subarachnoid haemorrhage
  1. Sanne M Dorhout Mees1,*,
  2. Daniela Bertens1,
  3. H. Bart van der Worp1,
  4. Gabriel J E Rinkel1,
  5. Walter M van den Bergh2
  1. 1 University Medical Center Utrecht, Netherlands;
  2. 2 UMC Utrecht, Netherlands
  1. Correspondence to: Sanne M. Dorhout Mees, Neurology, University Medical Center Utrecht, Heidelberglaan 100, PO box 85500, Utrecht, 3508 GA, Netherlands; s.m.dorhoutmees{at}


Background: In patients with aneurysmal subarachnoid haemorrhage (SAH), headache typically is severe and often requires treatment with opioids. Magnesium has analgesic effects in several conditions, but whether it reduces headache after SAH is unknown.

Methods: In a cohort of 108 SAH patients included in the randomized controlled trial Magnesium in Aneurysmal Subarachnoid Haemorrhage-II (MASH-II), severity of headache was regularly assessed on an eleven-point scale until day 10 after SAH. Headache was treated according to a standardised protocol with acetaminophen, codeine, tramadol, or piritramide. Serum magnesium levels were assessed every other day. Differences in mean headache scores between patients with mean high (>1.0 mmol/L) and normal (≤1.0 mmol/L) magnesium levels were analysed with a Student's t-test. Crude and adjusted odds ratios (OR) for the use of codeine, tramadol, and piritramide for patients with high versus normal magnesium levels were calculated with logistic regression.

Results: The 61 patients with high magnesium levels had lower mean headache scores (4.1) than the 47 patients with normal magnesium levels (4.9; mean difference, 0.8; 95% CI, 0.1to1.6) and required less tramadol (adjusted OR, 0.3; 95% CI, 0.1to0.7) or piritramide (adjusted OR, 0.2; 95% CI, 0.1to0.5). There were no differences in the use of acetaminophen or codeine.

Conclusion: In SAH patients, elevated serum magnesium levels are associated with slightly less severe headache and less frequent use of opioids. These data imply that intravenous magnesium therapy, besides a supposed beneficial effect on outcome, also provides pain relief for SAH patients, for whom it might also improve functional outcome.

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