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Differential progression of brain atrophy in Parkinson disease with and without visual hallucinations
  1. Naroa Ibarretxe-Bilbao1,
  2. Blanca Ramirez-Ruiz1,
  3. Carme Junque1,*,
  4. Maria Jose marti2,
  5. Francesc Valldeoriola2,
  6. Nuria Bargallo2,
  7. Silvia Juanes1,
  8. Eduardo Tolosa2
  1. 1 University of Barcelona, Spain;
  2. 2 Hospital Clinic, Spain
  1. Correspondence to: Carme Junque, Psychiatry and Clinical Psychobiology, University o Barcelona, Casanova 143, Barcelona, 08036, Spain; cjunque{at}


Objective: To determine the course of cognitive deficits and the regional progression of brain atrophy in patients with Parkinson’s disease (PD) with and without visual hallucinations (VH).

Methods: We performed MRI and neuropsychological assessment at entry to the study and at follow-up (mean ± SD= 29.91 ± 5.74 months) in a sample of initially non demented 12 PD patients with VH, 14 PD patients without VH and 12 healthy controls (HC). Gray matter changes over time were assessed by means of voxel-based morphometry (VBM) and cognitive changes by an extensive neuropsychological battery.

Results: At follow-up, 75% of patients with VH developed dementia. The greatest decline was observed in verbal memory, semantic fluency, language comprehension andvisuoperceptive functions. None of the patients without VH met criteria for dementia and did not show worsening in cognitive functions over time. Patients with VH showed widespread limbic, paralimbic and neocortical gray matter loss, whereas in the PD without VH group gray matter loss was restricted to a small region in frontal cortex and cerebellum. We also found significant correlations between the changes in several cognitive functions and gray matter loss over time in PD patients with VH.

Conclusion: The presence of VH in PD determines a different cognitive outcome and a different pattern of progressive brain atrophy. PD patients with VH, unlike PD without VH, frequently develop dementia and show a widespread atrophy involving limbic, paralimbic and neocortical areas.

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