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Kinematic improvement following Botulinum Toxin-A injection in upper limb spasticity due to stroke
  1. Esteban Fridman1,*,
  2. Marcos Crespo1,
  3. Santiago Gomez Argüello1,
  4. Lorena Degue1,
  5. Mirta Villarreal1,
  6. Stephan Bohlhalter2,
  7. Lewis Wheaton2,
  8. Mark Hallett2
  1. 1 Institute for Neurological Research-FLENI, Argentina;
  2. 2 National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States
  1. Correspondence to: Esteban Fridman, Institute for Neurological Research-FLENI, Montañeses 2325, Buenos Aires, (C1428AQK), Argentina; efridman{at}


Background and purpose: Focal spasticity is a significant motor disorder following stroke. Botulinum Toxin Type-A (BoNT-A) is a useful treatment for it. We evaluated kinematic modifications induced by spasticity, and whether or not there is an improvement following injection of BoNT-A.

Methods: Eight stroke patients with upper limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex and age-matched normal volunteers acted as a control group.

Results: Repeated-measure ANOVA showed that stroke patients performed slower in comparison to the control group. Following treatment with BoNT-A there was a significant improvement in kinematics in stroke patients while in the control group performance remained unchanged.

Conclusions: Focal treatment of spasticity with Botulinum Toxin Type-A leads to an adaptive change in the upper limb of spastic stroke patients.

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