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Factor analysis of behavioural symptoms in Huntington's disease
  1. Hugh Rickards1,
  2. Jenny De Souza1,
  3. Marleen van Walsem2,
  4. Erik van Duijn3,
  5. Sheila A Simpson4,
  6. Ferdinando Squitieri5,
  7. Bernhard Landwehrmeyer6,
  8. The European Huntington's Disease Network
  1. 1Department of Neuropsychiatry, Birmingham and Solihull Mental Health Foundation Trust, Edgbaston, Birmingham, UK
  2. 2Rikshospitalet, Centre for Rare Disorders, Oslo, Norway
  3. 3Department of Psychiatry, Leiden University Medical Centre, Leiden, Netherlands
  4. 4Clinical Genetics Centre, Aberdeen, UK
  5. 5IRCCS-Neuromed, Pozilli, Italy
  6. 6Ulm University, Ulm, Germany
  1. Correspondence to Dr Hugh Rickards, Department of Neuropsychiatry, Birmingham and Solihull Mental Health Foundation Trust, Barberry Building, 25 Vincent Drive, Edgbaston, Birmingham B15 2FG, UK; hugh.rickards{at}


A principal-components factor analysis was performed on behavioural data obtained from the European Huntington's Disease Network REGISTRY study. 1690 valid assessments using the United Huntington's Disease Rating Scale Behavioural Rating Scale were included in the analysis. This large data set confirmed previous reports of distinct behavioural patterns within Huntington's disease comprising a depressive factor, a dysexecutive factor, an irritability factor and a psychosis factor.

  • Huntington's disease
  • factor analysis
  • behaviour
  • mental disorder
  • behavioural disorder
  • Huntington's

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  • Funding European Huntington's Disease Network.

  • Competing interests This study received no sponsorship and was led by the investigators. HR has sat on an advisory board for MEDA pharmaceuticals. He has been paid honoraria for work for Cambridge Laboratories. SAS received an honorarium from Cambridge Pharmaceuticals for consultancy.

  • Ethics approval Ethics approval was provided by the UK MREC.

  • Provenance and peer review Not commissioned; externally peer reviewed.