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Corpus callosum abnormalities in Wilson's disease
  1. J M Trocello1,
  2. J P Guichard2,
  3. A Leyendecker1,
  4. M Pernon1,
  5. P Chaine1,
  6. S El Balkhi3,
  7. J Poupon3,
  8. P Chappuis4,
  9. F Woimant1
  1. 1French National Centre of Wilson's disease (CNR Wilson), Lariboisière Hospital, Paris, France
  2. 2Neuroradiology, Lariboisière Hospital, Paris, France
  3. 3Biological Toxicology Laboratory, Lariboisière Hospital, Paris, France
  4. 4Molecular biology and biochemical laboratory, Lariboisière Hospital, Paris, France
  1. Correspondence to Dr Jean-Marc Trocello, Lariboisière Hospital, 2 rue Ambroise Paré, Paris 75010, France; jean-marc.trocello{at}


Introduction Wilson's disease (WD) with neurological presentation is associated with brain lesions classically localised in globus pallidus, putamen, thalamus, mesencephalon, pons and dentate nucleus. Lesions of corpus callosum (CC) have not been studied in a broad population of patients with WD.

Objective Evaluation of the frequency of CC lesions in patients with neurological symptoms related to WD.

Method The authors included all patients with neurological expression of WD, followed in the French national centre for WD who had a brain MRI between March 2006 and December 2008. The localisation of brain lesions was analysed and the frequency of lesions in CC evaluated. All patients were assessed using the Unified Wilson's Disease Rating Scale. For patients with abnormalities located in CC, a clinical dysconnexion syndrome was investigated.

Results Among 81 patients (45 men, mean age: 34.8 years, from 12 to 74 years) with neurological expression, 42% had white-matter lesions on fluid-attenuated inversion recovery MRI. 23.4% of patients presented CC lesions, limited to the posterior part (splenium). The severity of disability estimated by Unified Wilson's Disease Rating Scale was correlated with the presence of CC lesions on MRI.

Conclusion Abnormalities in CC are not unusual (23.4%). Together with lesions of basal ganglia, CC signal changes should suggest the diagnosis of WD.

  • Wilson's disease
  • MRI
  • copper
  • disconnexion
  • dystonia

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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.