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Clumsy hand syndrome due to a localised cortical lesion in the primary sensory cortex in neuromyelitis optica
  1. Sagiri Isose1,
  2. Masahiro Mori1,
  3. Nobuyoshi Takahashi2,
  4. Shoichi Ito1,
  5. Satoshi Kuwabara1
  1. 1Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
  2. 2Department of Rehabilitation Sciences, Chiba Prefectural University of Health Sciences, Chiba, Japan
  1. Correspondence to Sagiri Isose, Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan; sagiri-i{at}

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A 21-year-old right-handed woman suffered cervical myelitis in 1971, followed by two episodes of bilateral optic neuritis and four relapses of thoracic or lumbar myelitis through 1998. Her initial brain MRI in 1989 revealed no abnormality, which met the MRI criteria for multiple sclerosis. In 2009, her serum anti-aquaporin-4 antibody was found to be positive, and a diagnosis of relapsing neuromyelitis optica (NMO) was made on the basis of current diagnostic criteria. Although she was treated with oral prednisone at each attack, she had residual sensory impairment below the C3 spinal segment. Then, she experienced no relapse until 2010 without any immunotherapy.

In April 2010 (at age 60 years), she was admitted to our hospital for unsteady gait and clumsiness in her left hand of 8 days' duration. On admission, she could not walk …

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  • Funding This work was supported in part by the Health and Labour Sciences Research Grant on Intractable Diseases (Neuroimmunological Diseases) (SK) from the Ministry of Health, Labour and Welfare of Japan.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval This study was conducted with the approval of the Ethics Committee of Chiba University School of Medicine.

  • Provenance and peer review Not commissioned; externally peer reviewed.