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- normal pressure
- cognitive disorders
- CSF dynamics
- head injury
- cerebrovascular disease
- paediatric neurosurgery
- cerebral blood flow
Normal pressure hydrocephalus (NPH) is a potentially treatable form of dementia characterised by a triad of symptoms (dementia, gait disturbance and urinary incontinence).
This triad is not pathognomic and may also be seen in other degenerative brain diseases (DBD). Diagnosis of NPH is based upon the clinical history/physical examination, brain imaging and CSF dynamics evaluation.1 The regional cerebral metabolic rate for glucose (rCMRglu) has been extensively measured in DBD. However, few PET studies describe a heterogeneous pattern of metabolic alterations in NPH and there is no conclusive evidence at present of an increase in metabolism after insertion of a CSF shunt.2 3
This is a preliminary study reporting changes in PET rCMRglu in patients with NPH …
Competing interests None.
Ethics approval The Ethics Committee of the Catholic University of Rome approved this study.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement Raw data are available and have been included in table 1, and online supplementary tables 2 and 3.