Article Text

other Versions

Download PDFPDF
Short report
Deep brain stimulation for tremor resulting from acquired brain injury
  1. H A Sitsapesan1,2,
  2. P Holland1,2,
  3. Z Oliphant3,
  4. N De Pennington1,3,
  5. J-S Brittain1,4,
  6. N Jenkinson1,2,
  7. C Joint1,
  8. T Z Aziz1,2,
  9. A L Green1,2
  1. 1Oxford Functional Neurosurgery and Experimental Neurology, Oxford University, Oxford, Oxfordshire, UK
  2. 2Nuffield Department of Surgical Sciences, Oxford University, Oxford, Oxfordshire, UK
  3. 3Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxfordshire, UK
  4. 4Oxford University, Institute for Biomedical Engineering, Oxford, Oxfordshire, UK
  1. Correspondence to Dr Holly Sitsapesan, Nuffield Department of Surgical Sciences, Oxford University, University Offices, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK; hollysitsapesan{at}


Objectives To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).

Methods A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.

Results VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.

Conclusion VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.

  • Head Injury
  • Tremor
  • Neurosurgery
  • Movement Disorders
  • Electrical Stimulation

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.