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Facial onset sensory motor neuronopathy (FOSMN) syndrome: an unusual amyotrophic lateral sclerosis phenotype?
  1. Steve Vucic1,2
  1. 1Sydney Medical School Westmead, University of Sydney, Sydney, New South Wales, Australia
  2. 2Neuroscience Research Australia, Sydney, New South Wales, Australia
  1. Correspondence to Dr Steve Vucic, Sydney Medical School, Westmead, University of Sydney, Darcy and Hawkesbury Rd, Wentworthville, Sydney, NSW 2045 Australia; s.vucic{at}

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Facial onset sensory and motor neuronopathy (FOSMN) syndrome may represent an amyotrophic lateral sclerosis phenotype as indicated by associated with the heterozygous D90A superoxide dismutase-1 (SOD-1) gene mutation.

Facial onset sensory and motor neuronopathy (FOSMN) syndrome is a rare and slowly progressive neurological disorder heralded by development of sensory symptoms within the face (trigeminal nerve distribution), and followed by evolution of sensory and motor deficits in a rostral-caudal direction.1 The motor deficits are characterised by lower motor neurone features including muscle weakness and wasting, cramps and fasciculations, with absence of …

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  • Contributors SV wrote the editorial commentary.

  • Competing interests Dr Vucic has no competing interests.

  • Provenance and peer review Commissioned; internally peer reviewed.

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