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Research paper
Dietary salt intake and time to relapse in paediatric multiple sclerosis
  1. Bardia Nourbakhsh1,
  2. Jennifer Graves1,
  3. T Charles Casper2,
  4. Sabeen Lulu1,
  5. Amy Waldman3,
  6. Anita Belman4,
  7. Benjamin Greenberg5,
  8. Bianca Weinstock-Guttman6,
  9. Gregory Aaen7,
  10. Jan-Mendelt Tillema8,
  11. Janace Hart1,
  12. Jayne Ness9,
  13. Jennifer Rubin10,
  14. Lauren Krupp11,
  15. Mark Gorman12,
  16. Leslie Benson12,
  17. Moses Rodriguez8,
  18. Tanuja Chitnis12,
  19. John Rose13,
  20. Lisa Barcellos14,
  21. Emmanuelle Waubant1
  22. for the Network of Pediatric Multiple Sclerosis Centers
  1. 1UCSF Regional Paediatric MS Center, San Francisco, California, USA
  2. 2Department of Paediatrics, University of Utah, Salt Lake City, Utah, USA
  3. 3Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  4. 4Department of Neurology, SUNY Stony Brook, Stony Brook, New York, USA
  5. 5Department of Neurology, UT Southwestern, Dallas, Texas, USA
  6. 6The Paediatric MS Center at the Jacobs Neurological Institute, SUNY Buffalo, New York, USA
  7. 7Department of Child Neurology, Loma Linda University, Loma Linda, California, USA
  8. 8Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
  9. 9Alabama Paediatric MS Center, Birmingham, Alabama, USA
  10. 10Department of Paediatric Neurology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA
  11. 11Department of Neurology, New York University, New York, New York, USA
  12. 12Partners Paediatric MS Center, Massachusetts General Hospital, Boston, Massachusetts, USA
  13. 13Department of Neurology, University of Utah, Salt Lake City, Utah, USA
  14. 14Department of Epidemiology, UC Berkeley, Berkeley, California, USA
  1. Correspondence to Dr Bardia Nourbakhsh, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Room 221F, P.O. Box 3206, San Francisco, CA 94158, USA; bardia.nourbakhsh{at}


Background Salt intake was reported to be associated with increased clinical and MRI activity in adult patients with relapsing-remitting multiple sclerosis (MS).

Objective To determine if salt intake is associated with time to relapse in patients with paediatric-onset MS.

Methods Paediatric-onset MS and patients with clinically isolated syndrome (CIS) within 4 years of disease onset were recruited from 15 paediatric MS centres in the USA as part of a case–control study. Patients with available prospective relapse data subsequent to enrolment were included in this project. Dietary sodium intake was assessed by self-report questionnaire using the validated Block Kids Food Screener. Cox proportional-hazards regression models were employed to determine the association of sodium density, excess sodium intake and sodium density tertiles with time to relapse following study enrolment, adjusting for several confounders.

Results 174 relapsing-remitting MS/CIS patients were included in this analysis (mean age of 15.0 years, and 64.9% females). Median duration of follow-up was 1.8 years. In an unadjusted analysis, density of daily sodium intake was not associated with time to relapse, and patients with excess sodium intake had no decrease in time to relapse as compared with patients with non-excess sodium intake. The multivariable analysis demonstrated that patients in the medium and high tertile of sodium density had a HR of 0.69 (95% CI 0.37 to 1.30, p=0.25) and 1.37 (95% CI 0.74 to 2.51, p=0.32) compared with patients in the lowest tertile, respectively.

Conclusions Higher salt intake was not associated with decreased time to relapse in patients with paediatric-onset MS.

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