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Contributors HF contributed to the acquisition of data, study design, statistical analyses, interpretation of data, drafting/revising of the manuscript for intellectual content and gave final approval. KPN contributed to the acquisition of data, interpretation of data, drafting/revising of the manuscript for intellectual content and gave final approval. JT contributed to analysis of the blood samples, drafting/revising of the manuscript for intellectual content and gave final approval. LL contributed to the study design, analysis of blood samples, drafting/revising of the manuscript and gave final approval. RJC and TTY contributed to acquisition of data, drafting/revising of the manuscript for intellectual content and gave final approval. NK contributed to the study design, statistical analysis, interpretation of the data, drafting/revising of the manuscript and gave final approval.
Funding This research was supported by the Ministry of Health Healthcare Research Scholarship, Master of Clinical Investigation, Singapore and National Neuroscience Institute, Singapore.
Competing interests None declared.
Patient consent Obtained.
Ethics approval SingHealth Institutional Ethics Review Board.
Provenance and peer review Not commissioned; externally peer reviewed.