Anti-myelin oligodendrocyte glycoprotein antibody can be detected in NMOSD phenotype of CNS inflammatory diseases negative for anti-aquaporin-4 antibody

Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein exclusively expressed on the surface of the myelin sheath in the central nervous system (CNS). Although the precise function of MOG is yet unknown, it is possibly related to the maintenance of the myelin structure. MOG has been of great interest because of its association with demyelinating diseases, particularly in multiple sclerosis (MS). It has also been used as an antigen to induce experimental autoimmune encephalomyelitis (EAE) in rodents as an animal model of MS. EAE induced by MOG peptides may develop inflammatory demyelinating CNS lesions dominantly in the optic nerves and the spinal cord. Although …