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Mechanisms of poststroke fatigue
  1. William De Doncker1,
  2. Robert Dantzer2,
  3. Heidi Ormstad3,
  4. Annapoorna Kuppuswamy1
  1. 1Institute of Neurology, University College London, London, UK
  2. 2Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
  3. 3Faculty of Health and Social Sciences, University of South West Norway, Oslo, Norway
  1. Correspondence to Dr Annapoorna Kuppuswamy, University College London Institute of Neurology, London WC1N 3BG, UK; a.kuppuswamy{at}


Poststroke fatigue is a debilitating symptom and is poorly understood. Here we summarise molecular, behavioural and neurophysiological changes related to poststroke fatigue and put forward potential theories for mechanistic understanding of poststroke fatigue.

  • stroke
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  • Contributors AK conceptualised the review. All authors contributed equally to the writing of the review.

  • Funding Wellcome Trust (202346/Z/16/Z).

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.

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