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Subregional heterogeneity of somatosensory dysfunction in the insula
  1. Kana Matsuda1,2,
  2. Masayuki Satoh3,
  3. Ken-ichi Tabei1,3,
  4. Yukito Ueda2,
  5. Ai Itoh1,
  6. Hidehiro Ishikawa1,
  7. Ko Matsuo4,
  8. Akihiro Shindo1,
  9. Masaru Asahi5,
  10. Atsushi Niwa6,
  11. Keita Matsuura1,
  12. Hidekazu Tomimoto1,1
  1. 1 Department of Neurology, Mie University Graduate School of Medicine, Tsu, Japan
  2. 2 Department of Rehabilitation, Mie University Graduate School of Medicine, Tsu, Japan
  3. 3 Department of Dementia Prevention and Therapeutics, Mie University Graduate School of Medicine, Tsu, Japan
  4. 4 Department of Neurology, Japanese Red Cross Ise Hospital, Ise, Japan
  5. 5 Department of Neurology, Yokkaichi Hazu Medical Center, Yokkaichi, Japan
  6. 6 Department of Neurology, National Mie Hospital, Tsu, Japan
  1. Correspondence to Kana Matsuda, Depertment of Neurology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan; m-kana{at}clin.medic.mie-u.ac.jp

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Introduction

Somatosensory functions are subdivided into two large groups: the elementary somatosensory functions, which consist of light touch, pain, thermal sensation, joint position sense and vibration sense, and the intermediate somatosensory functions, which include two-point discrimination, tactile localisation, weight, texture and shape perception. It is generally accepted that the functional localisation of somatosensory function is the postcentral gyrus, but some researchers suggested that the insula is also involved in somatosensory function.1

Insula is a multimodal area and has a major role as a convergence zone implicated in the coordination between internal and external information through emotional subjective awareness. However, the subregional specificity of somatosensory functions in the insula has not been fully elucidated.2 We experienced three cases of stroke restricted exactly to the subregions of the insula which showed heterogeneous somatosensory dysfunction. For these patients, we performed a close examination of the intermediate somatosensory function, and discussed the relation between the insula and intermediate somatosensory function.

Patients and methods

Patient 1

An 81-year-old, right-handed woman who had difficulty speaking in February 2017 was transferred to our hospital. MRI revealed a lesion in the right middle insula (figure 1A). The symptom improved at the time of hospital arrival and she underwent the best medical treatment. The symptom disappeared on the next day. Intelligence and elementary somatosensory functions were normal. The results of the intermediate somatosensory examinations showed that two-point discrimination, tactile localisation and graphesthesia were significantly impaired.

Figure 1

MRI findings of the cases presented. (A) Patient 1 had a cortical lesion in the right middle insula. (B) Patient 2 had a cortical lesion in the …

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