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The effect of changing arterial blood pressure and carbon dioxide on cerebral blood flow
  1. Jean Claude Baron
  1. Neurology, Hopital Sainte-Anne, Paris CB2 2QQ, France
  1. Correspondence to Professor Jean Claude Baron, Neurology, Hopital Sainte-Anne, Université de Paris, Inserm U1266, Paris 75014, France; jean-claude.baron{at}

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The short article entitled ‘Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures’, published in 1965 in the JNNP by A Murray Harper and HI Glass,1 is among the most cited articles ever published in the journal (429 citations as of 21 January 2020). Interestingly, the same first author published the subsequent year in the JNNP another highly cited article2 on a closely related subject (372 citations as of 2020).

The effect of changing arterial blood pressure and carbon dioxide on cerebral blood flow

Authors: Harper AM, Glass HI

Year Published: 1965

Number of times cited: 548

The Harper and Glass 1965 article was the first to assess the effects of changes in the arterial partial pressure of CO2 (PaCO2) on the cerebral circulation in conditions of normal arterial blood pressure, moderate hypotension and severe hypotension. To this end, the authors applied in anaesthetised mongrel dogs the technique that Lassen and Ingvar had just developed to measure quantitative regional blood flow of the exposed cerebral cortex using radioactive krypton injected in the internal carotid artery.3

The strong effects of changes in PaCO2 on the cerebral vasculature, first discovered in 1928 by Forbes and Wolff via direct observation of the pial arteries through a glass window in animals, …

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